Storm Reid ( Storm Reid )

Meg Murry

Oprah Winfrey ( Oprah Winfrey )

Mrs. Which

Reese Witherspoon ( Reese Witherspoon )

Mrs. Whatsit

Mindy Kaling ( Mindy Kaling )

Mrs. Who

Levi Miller ( Levi Miller )

Calvin O'Keefe

Deric McCabe ( Deric McCabe )

Charles Wallace Murry

Chris Pine ( Chris Pine )

Dr. Alex Murry

Gugu Mbatha-Raw ( Gugu Mbatha-Raw )

Dr. Kate Murry

Zach Galifianakis ( Zach Galifianakis )

The Happy Medium

Rowan Blanchard ( Rowan Blanchard )

Veronica Kiley

Michael Peña ( Michael Peña )

Red

André Holland ( André Holland )

Principal Jenkins

Bellamy Young ( Bellamy Young )

Camazotz Woman

David Oyelowo ( David Oyelowo )

The It (voice)

Conrad Roberts ( Conrad Roberts )

Elegant Man

Lyric Wilson ( Lyric Wilson )

Young Meg

Yvette Cason ( Yvette Cason )

Mrs. Teacher

Will McCormack ( Will McCormack )

Mr. Teacher

Daniel MacPherson ( Daniel MacPherson )

Calvin's Father

Akemi Look ( Akemi Look )

Air Force Officer

Tim Kang ( Tim Kang )

School Superintendent

Michele Norris ( Michele Norris )

Radio News Broadcaster (voice)

Claire Montwill ( Claire Montwill )

Student

Catelynn Brown ( Catelynn Brown )

Meg Double

Ariyah Brown ( Ariyah Brown )

Meg Double

Losa Fifita ( Losa Fifita )

Meg Double

Joyce Larkin ( Joyce Larkin )

Mrs. Who Double

Teonee Motley ( Teonee Motley )

Mrs. Which Double

Jessica Rockwell ( Jessica Rockwell )

Mrs. Whatsit Double

Oz Kalvan ( Oz Kalvan )

Charles Wallace Double

Isaac Ordonez ( Isaac Ordonez )

Charles Wallace Double

Kai Miller ( Kai Miller )

Charles Wallace Double

Leighton Leevard ( Leighton Leevard )

Charles Wallace Double

Guillaume Seeleuthner ( Guillaume Seeleuthner )

Charles Wallace Double

Jacob Eddington ( Jacob Eddington )

Charles Wallace Double

Easton Tath ( Easton Tath )

Baby Charles Wallace

Giselle Paredes ( Giselle Paredes )

Baby Charles Wallace

Punnavith Koy ( Punnavith Koy )